In the shadowed networks of Tokyo in 2039, Alice and Kaoru Mikogami confront the lingering fallout from their operation against a notorious CIA hacker. The target's digital remnants have begun infiltrating the city's vast data streams, reaching into the minds of those already ensnared by addictive substances. As the agents work to trace and limit this spreading influence, they find the virtual presence steadily gaining ground, turning the interconnected web into an ever more elusive domain.